The aim of this study was to investigate the link between khat abuse and the experience ofrndepression among people who are under treatment for substance abuse program inrnrehabilitation centers. The study was carried out in Sitota and Abichu mental health clinics.rnThe current study aimed to explore the development of depression as a result of khat abusernusing a qualitative research methodology, to explore respondents‟ own accounts of substancernuse and how they make sense of these experiences, their trajectory towards khat use as wellrnas their motivation for treatment. A qualitative research design was employed, drawing onrnthe interpretive framework which seeks to understand how people make sense of theirrnexperiences. The qualitative data was gathered through in-depth interviews (N=9) and focusrngroup discussions (N=14).The study found that peer pressure and psychological painrnexperienced played a motivating role in their substance use. The study has figured outrnmultiple perceived reasons for khat abuse and it‟s impact.