The main purpose of this study was to identify the factors that affect the implementation of student-centered approach in upper primary schools in Chomen Guduru Woreda. Some of the factors include the school administrator and teachers` commitment, classroom conditions, instructional facilities, teachers training and subject matter knowledge and communication between teachers and school leaders. Mixed methods approach was used to undertake this study (qualitative and quantitative). First, the Woreda was selected by availability sampling method and simple random sample was used to select schools. Again, simple random sampling technique was employed to select participant of the study. Thus, the participants of this study were 9 school leaders, 38 teachers and 65 students. The instruments of data collection were questionnaire, observation checklist and interview. The data were analyzed using frequency and percentage. The findings of the study indicated that the implementation of student centered approach was affected by three major factors. These are teachers, students and school facility related factors. Finally, the following recommendations were forwarded, it is important to conduct pre- service training of teachers to improve implementation of active learning strategies. Moreover, teachers should have to develop self-commitment for implementation of active learning methods. Educational officials should have to timely effective communication and organize workshop to update the knowledge and perception of teachers for implementation of active learning methods. The school leaders, parent teacher association (PTA) and Kebele School Board (K.Sc.B) work cooperatively in the construction of extra classroom to maintain the standard numbers of students in the classroom which is the most serious for implementing active learning. Key words: Student -centered approach, Upper primary schools, Chomen Guduru Woreda