In Vitro Evaluation Of The Activity Of Some Ethiopian Traditional Medicinal Plant Crude Extracts Against Plasmodium Falciparum
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The crude extracts of six Ethiopian medicinal plantsrnused traditionally for the treatment of malaria werernscreened for their in vitro anti-malarial activity.rnMethanol, chloroform and ethanol extracts of the sixrnspecies of plants, Croton m'::rostachyus Del.rn(Euphorbaceae): Calpurnia aurea (Alt.) Benth. (Fabaceae);rnBuddeleia polystachya Fresen. (Loganiaceae); Terminaliarnschimperiana Hochst. (Comberetaceae); Dodonaea angustifoliarnL.f (Sapindaceae) and Jasminum grandiflorum L. (Oleaceae),rnwere tested for possible schizonticidal effects. Of thernextracts screened, methanol extract of £.macrostachyusrnfruits and Q.angustifolia seeds; and chloroform extracts ofrn£. aurea leaves and £.macrostachyus fruits had lCSO values ofrnless than 10 ~g/ml showing a high anti-malarial activity.rnThe ethanolic extracts of £.macrostachyus fruits,rn!.schimperiana leaves; methanol extracts of !.schimperianarnleaves and £. aurea leaves, !l. grandiflorum root and bark;rnchloroform extracts of l!. polystachya leaves; Q. angustifoliarnseeds, !l.grandiflorum root and bark: and !. schimperianarnleaves possessed low activity with lCSO values between 11-50rnpg/ml. All other solvent extracts of the plants had nornactivity.
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