The purpose of this study was to examine the role of human resource management practices on the performance of Banking sector CBE as the case study. To achieve this the study was guided by the following objectives; to analyze the influence of recruitment practice to the performance on the Bank, to determine the effect of training and development on the performance of the Bank, to ascertain the contribution of team building practice on the performance of the Bank and to determine the influence of rewards and compensation on the performance of the Bank.rnThe study adopted an explanatory research design. Stratified random sampling was used to determine the sample size. The study targeted CBE HR management totaling to 55 people, the sample size was 40 respondents. The study used both primary and secondary data, where questionnaires, interview and annual reports of CBE were used. Primary data for the study was collected using structured questionnaires that were administered to the respondents. Quantitative data obtained from close ended questions were analyzed by using descriptive statistics. Narrative data obtained from interviews and open ended questions in the questionnaire were analyzed using qualitative approaches. Data collected was analyzed through SPSS version 26.Data analysis involved statistical computations for averages, percentages, and correlation and regression analysis.rnFrom the study, it is concluded that there is a positive perception of overall human resource management practices in the bank. Training programs, participative work settings, impartial recruitment and incentive arrangements provide proper motivation and combine to enhance organizational goalsâ€™ achievement in terms of greater quality services, productivity and innovation, reduces turnover employees, lower customer complaints. It is recommended that commercial bank of Ethiopia should develop and document human resource management strategies that are linked with the overall banks strategy