The study topic incited to conduct a survey because there was no prior research on this specific topic in Ethiopia. Its major objectives were to examine, assess and to investigate about the effect of Job Characteristic on Job Satisfaction at FDRE MOFA in A.A. Lack of system, mismanagement and intentional favoritism which were identified with the problem statement that can affect employee job satisfaction were investigated. The reliability statistics test with Cronbachâ€™s Alpha for all group of item shows above 0.9. Methodological part consists different types of methods which are research design, approach and the data collecting, analyzing, presenting and interpreting methods. Mainly the descriptive, inferential statistical technique; correlation and regression analysis method were applied to get the study finding. The gather data were analyzed by using the Statistical Program for Social Science (SPSS) version 25. The analyzed data included all the independent core dimension of job characteristic (CDJC), the three psychological states and job satisfaction factor variables and a dependent i.e. variable job satisfaction. Probability sampling method utilized with proportionate stratified random sampling formula was applied, the sample size determined for each stratum and the total sample size of 107 had been taken from 503 target population. Then, Questionnaires were distributed to 90 respondents who participated from both diplomatic and administrative & technical sectors at the Head Office of MOFA. The study major finding shows the grand average mean of five CDJC scores were below the average mean 2.91 and SD= 0.755, from these finding total feedback indicated the low mean 2.63. In addition, the knowledge of result items scored below the average, 3.75, which are related to feedback items through the path of psychological states. From the eleven job satisfaction factors the compensation and benefit (CB) items show minimum average mean 2.97 and SD= 0.879. Furthermore, the coefficients of total job satisfaction and all the CDJC coefficients result indicates the collinearity statistics does not have problem on tolerance and VIF. Total task significance has high correlation coefficient with total task identity i.e., 0.480. The highest coefficient of beta value = 0.319, highly significant = 0.003 for feedback, higher zero order correlation with employee job satisfaction = 0.451. Therefore, as the finding indicated the compensation and benefit pay structured system and the feedback system needs change to maximize employee satisfaction at the ministry