This study aims at finding out the audiences' response regarding Debub FM 100.9 programsrnwith particular reference to issues related to health. In light of this, attempts were made tornassess audiences' program preference, their purpose for listening to the program, and somernfactors influencing their reception towards the program. Regarding related literature,rnattempts have also been made to review various literatures written in related with the theme.rnAccordingly, different theoretical frameworks with particular emphasis to the uses andrngratifications approach were presented and discussed.rnThe research method used in this study was quantitative approach. Hence, in order to findrnanswers to the research questions, questionnaire was used as a major instrument of datarncollection. Accordingly, three hundred questionnaires were distributed to a randomlyrnselected subjects of Hawassa city residents and Hawassa University students. Factors likernage, sex, education, occupation, and place of residence were considered to be among thernissues that could influence the response of audiences for a particular media text.The analysis of the data shows that age, gender, and education factors were important inrninfluencing the audiences' program (genre) preferences, and their opinions towards thernspecific program called "Sile Tenawo Yiteyiku". As (McQuail, 2000) states the need ofrnaudiences varies according to their experience, gender and educational levels. Thus, thernfinding reveals instances whereby majority of male respondents preferred to listen to newsrnand educational programs than fema le respondents.rnWhat is more , the findin g also indicates that s ign ificant majority of the respondents in allrnage groups agreed that " Sile Tenawo Yiteyiku " is certainly educative. However, few of thernyounger participants viewed the is sues rai sed in the program in a negat ive way. On the otherrnhand, place of re sidence and occupation differences were not that much critica l factors inrninfluencing audience reception in thi s study. With reference to occupation, the analysisrnshows that the tran smission time of "Sile Tenawo Yiteyiku" was un suitabl e for thernoverwhelming majority of the re spondents, especially for tho se who were students andrngovernment employees. Based on the findings, the stud y ha s made some pertinentrnrecommendations.