The Elhiopian governmenl designed a conslillilion Ihal have a democralic and In/ilion righlsrnIhal gllaranleedjor Ihe cilizen ajier Ihefcdl of Derg regime. All peoples o.lElhiopia have arnpro/ect;on as national and regional in both international convention and Domes/ic lall'srnwilhinlhe cOllntry. Th is study was designed to assess the foctors affecting interregional ConflictrnResolulion in Gromia and Somali regions o.l Elhiopia. In order to address the researchrnobjective. Ih is sludy employed both Ihe descriptive and explanatOlY research design. Moreover.rnboth qualitative and quantilative research approaches were employed since mixed methods helpsrnto make use of different data source. Data were collected Fom prilllwy and secondwJI sourcesrnIhrough questionnaires, inlerviews, doclimenl review. FGD and observalion. The researcher lIsedrnboth probability and non probability sampling lechniques to draw Ihe sample. In tOlal, 50 highrnexperts. 15 elders, 10 leaders 10 persons Fom diffirent sociel ies were selected randomly and 25rnkey informants were plllposefidly selected. Finally, the raw data collected through the surveyrnwere analyzed based on qualilative and qUClntitalive dolo analysis /echniques involvingrndescriplive and SPSS analysis. From this analysis 10 bring sllslainable peace wilhin Ihe 1110rnregions were Ihe major problems wilhin the Slake holders. The SIIlC0' also found Ihalrndijjerenliale the root cause and trigger or immediate cause of the two regions, IInclearrndemarcalion of lerrilorial arrangemenl as a rejerendum and Ihe miss use ollegal bindingrnaclors are anolher problems. So, in order 10 accommodale Ihe two regions people beneficialrndifferenlialions beller 10 have solve demarcalion ollerrilorial bOllndaries problems andrnmediate genuinely andjustice .