The main purpose of this study was to assess the causes and effects of marginalization of rnManjo clan in Kafa Zone Saylem Woreda. Accordingly, the study employed descriptive rnsurvey design. The main sources of data for the study were three Kebeles that found in rnSaylem Woreda. In order to select the sample respondents, systematic random and rnpurposive samplings were used. Thus, 280 respondents (126 Manjos and 154 non Manjos) were selected on the basis of systematic random sampling. Besides, eleven (11)rnpeople were selected through purposive sampling for interview. Both quantitative and rnqualitative data were collected using questionnaire and interview guide. The analysis of rnthe quantitative data was carried out using percentage, mean and standard deviation rnwhile the qualitative data was analyzed using narration and theme building. The result of rnthe study disclosed that the Manjos in the studied kebeles were marginalized and suffered rnfrom the effects of their marginalization. The findings also revealed that marginalization rnof Manjo was caused by their linage or descent, low occupational status, breaches of rnfood taboo, contradictory cultural practice, hygiene problem and problem of rncharacteristics. The study also depicted that the consequences of marginalization ofrnManjo clan were socio cultural (absence of social relation, denial of communality, rnprohibition of intermarriage, denial of burial process and denial of membership in rncommunity organizations), economic ( limitation of access to participate, absences of rnfavorable working place, restriction of exchange in the market, limitation of products and rnengagement in less valued works) and political (limitation of opportunity to take part in rnand lack of their own representative). The study also founded that the possible strategies rnto reduce marginalization of Manjo were awareness creation, providing opportunity, rnempowerment and protection. Based on the findings of the study, it was recommended rnthat the government agencies, religious institutions, NGOâ€™s and local administrators in rnthe study area should collaboratively work hard to reduce marginalization of Manjo clan rnand maintain health socio-cultural, economic and political relationship withManjo