The general objective of this research paper is to study factors affecting humanitarianrnsupply chain performance: the cases of Action-Against-Hunger (AAH) and Medecines SansrnFrontiers (MSF-Spain). The study employed both descriptive and explanatory researchrndesigns. Moreover, it employed a mixed research approach that involved quantitative andrnqualitative methods. Both primary and secondary data were collected and used for thernstudy. The three factors that have been examined in this study are endogenous factorsrn(human resource turnover, lack of performance metrics, lack of coordination, limitedrnaccess to information system technology), situational exogenous factors (degradedrninfrastructure, environmental factors, socio-economic factors, governmental factors andrndonor restrictions) and non-situational exogenous factors (uncertainty and time pressure).rnThe research is based on responses solicited from cross section of employees of ActionAgainst-Hunger and Medecins Sans Frontires(MSF-Spain). A total number of responsesrnfrom 47 employees were used for analysis in this research study. With regard to samplingrnmethod, the study did not undertake rigorous statistical sample size calculation ratherrnconsidered census method due to the limited population size of the study. Questionnairesrnwith closed ended and five point Likert scale items were used as instrument to collect datarnfor the research. The data collected were analyzed using SPSS 20.0 Version. Descriptivernstatistics was used to explain the demographic characteristics of respondents and torndiscuss the descriptive report of responses provided by the respondents on humanitarianrnsupply chain practices and performance by measuring mean and standard deviation.rnResearch questions were tested using statistical analysis of Pearsonâ€™s Correlation andrnmultiple linear regressions. The finding indicates that humanitarian supply chain practicesrnsuch as procurement, inventory management, warehouse and transportation were properlyrnpracticed in the organizations. Moreover, the overall supply chain performance of AAHrnand MSF-Spain is flexible; cost-efficient; reliable and responsive. Factor analysis wasrnconducted using the Kaiser-Meyer-Olkin(KMO) measure of sampling adequacy and thernresult has revealed all the KMO values where above 0.5 and were acceptable. Independentrnsample t-test was conducted using Independent Samples Mann-Whitney U Test to identifyrnif there is mean difference between the two groups (Action-Against-Hunger and MSFSpain) and the result has revealed that there is no mean difference between the two groups.rnThe multiple regression result has shown that human resource turn over, lack ofrnperformance metrics, lack of coordination and limited access to information systemrntechnology (endogenous factor), degraded infrastructure, socio-economic factors,rnenvironmental factors, and donor restriction(situational exogenous factors) andrnuncertainty and time pressure(from non-situational exogenous factors) are significantlyrnaffecting humanitarian supply chain performances of AAH and MSF-Spain. However,rngovernmental factor has been reported as less significant. Therefore, this study suggestsrnfuture researchers to find out if this variable does not have effect on humanitarian supplyrnchain performance. Overall, based on the inferential statistical result, this studyrnrecommends both organizations to focus on endogenous factors in general and humanrnresource turnover, infrastructural factors and lack of coordination among humanitarianrnsupply chain actors in particular.