Background: Inhalant abuse is one of the major forms of substance abuse which refers to the harmful orrnhazardous use of diverse groups of volatile and psychoactive substances found in a number of commonrnproducts such as adhesive glue, typewriter correction fluid, paint stripper, gasoline, and many others.rnThe volatile solvents found in these substances affect different organs and systems of the body.rnAdhesive glue sniffing, a form of these inhalants is becoming a common event in the major cities ofrnEthiopia, where street individuals are the most vulnerable groups. However, little was known about thernassociation between adhesive glue sniffing and the liver enzymes and electrolytes of these adhesive gluernsniffers, particularly in the study area. rnObjective: To assess the effect of adhesive glue â€•(Mastish)â€– sniffing on selected liver enzymes andrnelectrolytes of street individuals in Addis Ababa, Ethiopia, April 2019. rnMaterials and Methods: Comparative cross-sectional study design with a convenience samplingrnmethod was applied. The study participants who were comparable in all other features were firstrnscreened for eligibility considering the factors that can affect the parameters. Eligible participants werernfirst interviewed with the questions prepared. Then blood sample collection for the biochemical testsrnwas drawn and quantified. Data were entered and cleaned with EpiData version 3.1 and then exported tornand analyzed using IBM SPSS statistics version 23. Descriptive statistics, independent samples T-testrnand Pearson correlation were the modes of analysis used. Data was described and presented usingrnfrequencies, summary measures, tables, and graphs. The level of significance was declared at p< 0.05. rnResults: Out of a total of 162 participants screened, all completed the study that gave 100% responsernrate. All of them were males and the sniffers had significantly lower body weight than the controlsrn(p=0.039). Most of them started sniffing adhesive glue due to peer pressure, found it from distributorsrnand continued sniffing for cold resistance. The levels of ALP, ALT, potassium and chloride werernsignificantly higher among the exposed group (p