Background: Pre-eclampsia is a common hypertensive disorder of pregnancy with a world widernprevalence rate of 3-5%. There is no curative drug to treat pre-eclampsia so far. Therefore,rnresearches on medicinal plants have paramount importance in discovering therapeutic and /orrnprotective agents from plants. rnObjective: To assesss the potential prophylactic and therapeutic effects of aqueous leaf extracts ofrnT. schimperi ï¼ˆALETSï¼‰ and M. stenopetala (ALEMSï¼‰ on preeclampsia through regulatingrnhemodynamic variables of rat models. rnMethods: a comparative controlled experimental study was undertaken on nitric oxide-nitro-Largininernrnmethyl ester (L-NAME) induced pre-eclampsia rat models. Then hemodynamicrnparameters such as blood pressure and blood flow velocities were evaluated using rat tail cuffrnblood pressure recorder and Doppler flow meter, respectively. Moreover, various biochemicalrnand biophysical parameters that have clinical significance in the pathogenesis of human preeclampsiarnwererninvestigatedrnafterrnadministrationrnofrnthernherbrnextractsrnwithrngastricrngavagerntornthernrntestrngroups.rnTorndeterminerntherneffectsrnofrnthernherbsrnonrnoxidativernstressrnofrnpre-eclampsia,rnserumrnlipidrnrnperoxidernlevelrnandrntotalrnantioxidantrncapacityrnwerernevaluated.rnLipidrnperoxiderncontentrnwasrnestimatedrnrnaccordingrntornthernmethodrnofrn(Ohkawarnetrnal.,rn1979).rnTACrnwasrnassayedrnusingrnthernmostrnwidelyrnusedrnrncolorimetricrnrnmethod-azinobis 2,2â€²3-ethylbenzothiazoline-6-sulfonate (ABTS) radical cathionrndecolorization assay. Histo-pathologic investigations on liver, kidneys and placenta tissues werernevaluated in each group. Moreover, ex-vivo tests were conducted to compare the vasomotionrneffects of extracts and fractions of both plant materials on intact and denuded thoracic aorta. rn rnResults:rnUntreated pre-eclamptic (PE) rat models had significantly deranged (p