Introduction: Liver, an imperative organ has a crucial role in the metabolism of xenobiotics that causes itrnto succumb to numerous hepatic diseases. Synthetic drugs exploited in the treatment of liver diseases arernincompetent and may sometimes lead to serious side-effects. In this context, herbal therapy has emergedrnas a proficient approach with good values in treating hepatic diseases. Ginger have been proven to berneffectual as hepatoprotective agent and it may serve as a vital source of potentially useful new compoundsrnfor the development of effective therapy to combat a variety of liver problems caused by many toxinsrnincluding carbon tetrachloride.rnObjectives: The present study was designed to explore the role of crude ethanol extract of ginger rhizomernon the biomarkers of CClrninduced hepatotoxicity in male Wistar albino rats. rnMethods: Twenty eight rats were used throughout the study. Rats were divided into four groups withrnseven in each. Group 1 (normal control) received 1mL/kg of corn oil, group 2 (standards) receivedrn350mg/kg vitamin E, group 3 (treated) received 200mg/kg crud ginger extract, group 4 (negative control)rnreceived 0.5mL/kg CClrn4rn4 rn. Liver toxicity was induced by intraperitoneal administration of CClrn dissolvedrnin 1mL corn oil at a dose of 0.5mL /Kg body weight.rnAdministration of crude ethanol ginger extract at a dose of 200 mg/kg body weight was started a weekrnafter CClrn treatment and was performed for five weeks (totally six weeks). rnResults: The results revealed that hepatotoxic rats supplemented with 200mg/kg showed a significantrndecrease in MDA, ALT and TP with the same p-value (p