Background: Hypertension is an elevation of arterial blood pressure greater than normal. HTN affects 1 billionrnpeople globally and accounts for approximately 7.1 million deaths annually. Dyslipidemia is abnormal lipidrnaccumulation in the body due to either defect in lipid metabolism or clearance. It is highly prevalent worldwidernincluding in Ethiopia, where it affects especially urban populations. Hypertension and dyslipidemia are highlyrncorrelated and they are significant risk factors for cardiovascular disorders. Some medicinal plants are used inrntraditional medicine for the treatments hypertension and dyslipidemia. Psidium guava (P. guava) is one medicinalrnplant which is widely cultivated and popularly used in traditional medicine treatment of diseases such as diabetes,rnvomiting, diarrhea and dyslipidemia.rnObjective: The study was designed to identify the effect of P. guava leaf extract on hypertension in guinea pigs.rnAnd also to investigate lipid profiles, liver function tests and weight of mice fed a high fructose diet.rnMaterials and Method: The study was conducted on twelve guinea pigs to measure the effect of P. guava leafrnextract by using invasive and organ bath methods. Other experiment was done on 30 fructose fed Swiss albinornmice to investigate the effect of P .guava leaf extracts on weight, lipid profiles and liver serum enzymes .rnFructose fed mice for four weeks were treated with different doses of extracts for additional three weeks whilernmaintaining high fructose diet. Then weight of mice were measured three times during the experiment. And alsornthe end of seventh week, animals were sacrificed and lipid profile (TC, TG, HDL-C and LDL-C ) and serumrnenzymes (AST, ALT and ALP) were analyzed by using chemical analyzer. The result was statically analyzed byrnusing paired t-test independent student t test, one â€“way ANOVA and mean comparison, Microsoft excel.rnResult: The ethanol extract of P. guava leaf showed a significant ability to relax isolated aortas of guinea pigs inrnex vivo experiments, after induction ofaortic muscle contraction by high potassium concentrations. P. guava leafrnextracts also lowered the systolic and diastolic blood pressure of live guinea pigs in in vivo experiments.rn.guava leaf extracts also significantly reduced the weight ,rnPrnimproved lipid profiles and reduces liver serumrnenzymes in fructose-fed mice.rnConclusion: The effect of P .guava leaf extract in reduction of hypertension, improvement of lipid profiles andrnpossible protection against liver damage may be due to numerous benefits of phytochemicals.rnKey terms: Psidium guava, hypertension, blood pressure, lipid profile, guinea pigs, mice, dyslipidemia, serumrnenzymes, hepatoprotective, effect.