In-vivo Anti-plasmodium Activity Of Crude Extracts And Solvent Fractions Of Strychnos Mitis Leaves In Plasmodium Berghei Infected Mice

Malaria is a major public health problem in the world which is responsible for death of millionsrnparticularly in sub-Saharan Africa. Today, the control of malaria has become gradually morerncomplex due to the spread of drug-resistant parasites. Medicinal plants are the unquestionablernsource of effective antimalarias. The present study was aimed to evaluate antiplasmodial activityrnand determine acute toxicity of Strychnos mitis in P.berghi infected mice. All extracts revealedrnno obvious acute toxicities on mice up to the highest (2000mg/kg) dose given.rnThe crude aqueous extract, crude hydromethanolic extract, N--hexane fraction of crudernhydromethanolic extract, chloroform fraction of crude hydromethanolic extract and aqueousrnfraction of crude hydromethanolic extract of the leaf of Strychnos mitis significantly (p

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