The Effects Of Ricinus Communis And Jatropha Curcas Seed Aqueous Extracts On The Histology Of Uterus And Ovary In Mice

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In developing countries, the problem of population explosion is still a major issue. To combatrnthis issue, many approaches were tried, but the contraception method through explorations ofrnmedicinal plants and their mechanism of action on reproductive tissues was found to be morernplausible. To this effect, a histological study on the effects of Ricinus communis and Jatropharncurcas seed aqueous extract on the reproductive tissues (uterus and ovaries) was done in thisrnstudy.rnThe fresh air dried seeds of R.communis and J.curcas were employed in the study. The J.rncurcas and R.communis seed aqueous extracts were daily administered by gavage to thernexperimental groups in a doses of therapeutic (1.5 g/kg and 0.02 g/kg), sub-toxic (3 g/kg andrn0.04 g/kg), and toxic (6 g/kg and 0.08 g/kg) body weight, respectively, to virgin Swiss AlbinornMice for 7 days. The standard groups were treated subcutaneously with a standard drug,rnEstradiol Benzoate (0.1mg/kg body weight per day) for the same period. The body weight of thernmice was recorded daily and they were all sacrificed on the 8th day under Diethyl Etherrnanesthesia. The uterus and ovaries were dissected out, cleaned of surrounding tissues andrnweighed on a semi-microbalance sensitive to 0.00 mg and effect of the extracts on the weightsrnof the genital organ weight was recorded. The tissues were fixed in Boun`s Fixative, andrnhistological tissue processing for light microscopy was performed. Histomorphometric analysisrnof the epithelial cell height, endometrial thickness, myometrial thickness of the uterus, and thernnumber of ovarian corpus luteum and atretic follicles were examined. For histopathologicalrndiagnosis, stereological studies of the uterine endometrial gland volume densities were alsorncarried out.rnxiirnNo statistically significant (P

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The Effects Of Ricinus Communis And Jatropha Curcas Seed Aqueous Extracts On The Histology Of Uterus And Ovary In Mice

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