The data pertaining to incidence, prevalence and situation of persons with disabilities inrnEthiopia are fragmentary and incomplete, which need more investigation. The objectives of thernstudy were determining the prevalence of PWDs and investigating their socio-economicrnconditions. In order to meet these objectives, both quantitative and qualitative methods were used.rnThe quantitative method was used to describe the prevalence of PwDs while the qualitative was employedrnto reveal the socio- economic condition. A multi-stage cluster sampling was used, classifying therntown in to three sub cities, then the three sub cities were divided in to seven kebeles. The kebelesrnwere divided in to twenty villages each. 1200 households were involved to respond tornquestionnaire to be filled about themselves and PWDs. The interview and focus grouprndiscussions were also used to collect data from PWDs and their families. The findings of thernstudy show that the prevalence of PWDs in Hosanna town accounts 1.83% of the totalrnpopulation, which is very low compared to the estimates of WHO 1980 (10%) and WHO and WBrn2011 (17.6%). There are various reasons for the difference between this finding and the WHOrndata. Some of these could be lack of awareness to identify the mild cases of disabilities byrnrespondents, and unwillingness to disclose their children with disabilities. The finding on thernsocio economic condition revealed that except the situation of deaf children and their familiesrnwho are in self reliance compared to the other PWDs. Most of the persons with physically,rnvisually and intellectually disabled are poor and beggars. They have no access to communityrnsocial services, and they are socially discriminated and ignored. Schools and education sectorsrnneed to include them in the regular classes. They need Community Based Rehabilitation centersrnas soon as possible