Pharmacognostic Study And Some Biological Activities Of Acacia Albida Del. (fabaceae) Root Bark

ABSTRACTAcacia albida Del (Fabaceae) is one of the largest thorn trees, reaching 30m in height, withspreading branches and a rounded crown. The bark is grey and fissure when old. It belongs to thefamily Fabaceae. The tree has medicinal value for treatment of respiratory infections andmalaria. The bark contains a lot of tannin and has been employed in industries. Phytochemicalscreening on the root bark extract reveal the presence of Tannins, Flavonoids, Saponins andAlkaloids and were quantitatively estimated to be 12.18, 7.93, 1.90, 0.43 w/w respectively. Thinlayer chromatography of the various constituents gave various spots with distinct Rf values.Antioxidant activity of the extract by 2,2- diphenyl-1-picric hydrazyl (DPPH) radical scavengingability revealed that with increase in concentration of extract radical scavenging activityincreases. The standard synthetic antioxidant: ascorbic acid has higher (99.08%) radicalscavenging activity than the plant extract at 0.5mg/ml, however the plant extract at the sameconcentration of 0.5mg/ml exhibited significant (P<0.01) radical scavenging activity of 91.48%.It thus shows a radical scavenging activity as close as that of the standard.Evaluation of the extract for glucose lowering effect revealed a significant (P< 0.05) reductionof high blood glucose level in alloxan induced diabetic rats from 335.33±3.3 on first daytreatment to 151±14.42 on 4th day treatment at a dose level of 200mg/kg body weight orally.These findings show that the root bark has antioxidant properties and hypoglycemic effects onalloxan induced diabetic rats. These may support the traditional use of the plant for diabeticmanagement.

Get Full Work

Report copyright infringement or plagiarism