The main purpo e of the study was to know the level of Muslim students knowledge,rnattitude, stigma and di crimination their under tanding of the Islamic approach to defendrnthe spread of HIV and to investigate their understanding and commitment to the expectedrnrole as a Muslim. The next purpose was to compare madrasa and high school studentsrnknowledge, attitude and other variables too. For this purpose 303 students from highrnschool (198) and madrasa (l05) respondents from Addis Ababa were selected. Mainly arnquestionnaire was employed to gather the required information from the subjects. Usingrnindependent sample t test the obtained data were analyzed and interpreted. As a result thernfollowing major findings were observed. Though both groups have good level ofrnknowledge, high school students have significantly better than madrasa students withrnsome limitation. In relation to attitude, stigma and discrimination, high school studentsrnwere found to have favorable attitude and less stigmatic and discriminatory behaviorrntowards the victims. While madrasa students' attitude was negative and they were morernof stigmatic and discriminators. The variation was also significant at alpha 0.0] level.rnRegarding the Islamic approach to the prevention strategy both groups agree to thernimportance but madrasa students significantly better in their understanding andrncommitment to this approach. Finally their understanding to the expected role wasrnassessed and high school students were found to be more responsible. The correlationrncoefficient showed that strong and positive relationship among variables with thernexception of prevention strategy with the other variables and it was significant for allrnvariables.rnFinally some important recommendations were forwarded so as to improve subjectsrn(especially madrasa students) knowledge, attitude towards PLHA, orphans and the like.rnOut of this teaching the religious leaders, making repeated open discussion with both thernclerics and madrasa students i required to improve their stigmatic behavior andrnunfavorable attitude. Enough attention shou ld be given to these groups so that they mayrnhelp in the pr0gess of defending and controlling the pandemic