The study was conducted from October, 2019 to May, 2020 by using cross-sectional study design tornassess a clinic-pathological, lesion characterization, and financial loss due to fasciolosis and hepaticrnnecrobacillosis in cattle slaughtered at three municipal abattoirs of central Ethiopia. Sixty cattle werernselected using systematic random sampling for this study, from which blood samples and liver tissue ofrnthe same animals were collected before and after slaughter, respectively. Tissue sampling for bacterialrnculture and histopathology were collected from the infected liver. Post-mortem inspection results, 41.6%rn(25/60) gross pathologic lesions, of these, 20% (12/60) were mixed infection of liverflukernand Fusobacterium necrophorum while 8% (5/60) and 13.3% (8/60) of the infections were duernto Fusobacterium necrophorum and liverflukes alone, respectively. The histopathologic examination ofrnthe affected livers indicated heavy infiltration of inflammatory cells, biliary cirrhosis and extensivernfibrous of connective tissue proliferation in the hepatic capsule. The hematological assay results indicatedrnthat PCV, Hb, and RBCâ€™s were lower in the infected cattle while, the WBCâ€™s (Eosinophilia, Neutrophilia,rnMonocyte, and Lymphocyte) were higher. The biochemical analysis of blood samples from the infectedrncattle showed that the liver enzymes AST, ALT, and ALP were significantly higher in animals withrnhepatocyte degeneration. The estimated financial losses due to liver condemnation by fascioliasis andrnhepatic necrobascillosis were 1,747,200 ETB/ ($56361.3) annually. Therefore, the study concluded thatrnthe liverflukes and infections due to Fusobacterium necrophorum are the major problems of cattlernslaughtered at the selected abattoirs of the study areas. Thus, corrective measures and furtherrninvestigations are recommended to lessen economic loss from fasciollosis caused liver condemnation.