Ninety strains of Shigella and forty-five strains of aslwoelrnSalmonella Here isola ted from 1000 adult dip,rrho eal ou t-pa tien tsrnfrom three hospitals and three clinics in Addis Ababa. Norn.Yersinia enteroco1i tica "as isolated.rnOut of the ninety Shigella strains, 57 (63. 3~b) HerernSh. flexneri, 17 ( 1 8 • 970) Sh. dysen teriae, 9 ( 10%) §!! .poydii andrn7(7.8%) §!!.sonnei, And among the forty-five Salmonella strains,rn17(37.8%) belonged to Group C, 13(28.9?b) Here Group B strains,rn9(20%) Here §.typhi,4(8.9) belonged to Group D other thanrn§..,!;yphi and Groups A and E had ono isolate each(2.2%).rnThe standardized agar disk diffusion technique ",as used Hithrndislcs of ampicillin, carbenicillin, chloramphenicol, cepha10thiri,rngentamicin, kanamycin, polymyxin B, streptomycin, sulphadiazine,rntetracycline, and trimethoprim-sulphamethoxazole,rnAll Shigella strains Hore sensitive to oepha10thin(95.6%),rngGntamioin(100%), kanamycin(100%) , polymyxin B(100%)andrntrimethoprim-sulphamethoxazole (1 007~). Sensi ti vi ty to ampicillinrn(47.7%), carbenicillin(50%), streptomycin(36 • 7%), sulphadiazinern(34.4?G) and tetracycline(31.1?b) Has very 10'", Only 15 strainsrnHere sensitive to all 11 drugo.rnNinety-threo percent of Sh.flexner=h,70.6% of §!!.dysenteriae,rn44.45'0 of §h.boydii and 71.45'0 of §!!.sonnei Here resistant one orrnmore drugs. About 82% of all Shigella strains Here resistant tornone or more drugs. J>!ulti;ole drug-resistance Has detected inrn82.4% of Sh.flexneri, 70.65'0 of Sh.Qysenteriae, 33.3% of §1a.boydiirnand 57.1% of §!!.sonnei. About 74')b of Shigella strains "lerernmultiply resistant, Eighteen different resistance patterns wererndetected, of which 26,7% ",ere simultaneously resistant tornampicillin, carbenicillin, chloramphenicol, streptomycin, sulpha•diazine,rnand tetracycline. This pattern ",as the commonest inrn§h. flexneri (31 %) and Sh.dysenteriae (2910).rnAll Salmonella strains "ere sensitive to gentamicin, polymyxinrnBand trimethoprim-sulphamethoxazole. All strains of GroupsA,Ernand §..typhi ",ere sensitive to all drugs. A total of 31 strainsrn(68.9%)",ere sensitive to all drugs.rnOver 85% of Group B strains ",ere sensitive to all drugs.rnGroup C strains ",ere the least sensitive. Ampicillin, 'C' , .rncarbenioillin, cephalothin, chlorampheniool, streptomyoin,rnsulphadiazine and tetracycline ",ere mostly i.net'f"Go't':lV