The main objective of this study was to explore the impact of Accounting Information Systems onrnthe organizational performance of the Pharmaceutical Fund Supply Agency in Ethiopia related torninventory management, customer welfare, operating cost and financial statements. The researcherrnused both primary and secondary data and used explanatory research method. The researcher usedrnrandom sampling technique and distributed questioners to the PFSA central and branch staffs andrnused Pearson correlation and simple linear regression to check the relationship and effect betweenrnthe variables respectively. The finding of this study showed that accounting information systems hasrna positive and significant impact on inventory management, financial statement, customer welfare ,rnorganizational performance and it has a negative relationship with operating cost. Therefore, thernresearcher concluded that accounting information system has a significant and positive impact onrnorganizational performance. The researcher recommends companies to use accounting informationrnsystem for better organizational performance.rnKey Words: Accounting information system, organizational performance, inventory management,rnfinancial statements, customer welfare, operating cost