The purpose of the study was to identify the relationship between information system success and businessrnperformance as well the extent of moderating effect of Accounting Information System effectiveness on thernabove relationship of Commercial Bank of Ethiopia (CBE). The researcher used both primary andrnsecondary data and used the explanatory research design. The researcher used a random samplingrntechnique and an online questionnaire through the google platform to the CBE branch staff and customersrnand used Pearson correlation, multiple regression, and moderate regression to justify the objective of thernstudy. The primary data are were collected through online based structured questionnaires and based onrnvalid and complete sample responses of 108 employees and 108 customers of CBE selected based onrnstratified random sampling method. The finding of this study showed that IS success has a positive andrnsignificant impact on business performance and AIS effectiveness has a positive and moderate effect inrnaffecting the relationship between IS success and business performance based on Service Profit Chainrn(SPC) model. Therefore, the researcher recommends companies should integrate information quality,rnservice quality and system quality in designing IS framework design in a holistic approach and take intornconsideration the effectiveness of AIS as moderating factor to benefit the level of business performancernexpected from the IS model.