Introduction. Cancer is a primary and devastating health problem. Because of largernpopulation growth and increased life expectancy, prevalence of cancer is rising. Thernimpact of cancer trajectory is beyond cancer patients as it affects the social environment ofrnthe patients. The effect of cancer on the psychological well-being of the caregivers ofrncancer patients could result a raised risk of psychiatric morbidity as relater to stressful lifernevents. However, the caregivers have been ignored or overlooked team. Earlyrnidentification and treatment of depression, can improve their physical and mental health,rntheir quality of life, limit suffering, and can improve their service/care giving role tornpatients with cancer. rnObjective. To determine prevalence of depression and associated factors among caregiversrnof cancer patients attending Hawassa university specialized hospital oncology unit, SouthrnEthiopia, 2019.rn Methodology. Institution based mixed study design will be conducted among familyrncaregivers of adult cancer patients attending Hawassa University Specialized Hospitalrnoncology unit. For quantitative method, convenient sampling technique considered to bernused and sample size determined by calculating using single population proportion andrnbecame 422 sample size. But the service takers are not more than 300 per month; becausernof this census technique will be considered. For qualitative method, purposive samplingrntechnique will be used and sample size will be determined based on the saturation of therninformation. The data will be collected using structured and semi-structuredrnquestionnaires. The data will be analyzed using SPSS version 24 and MAXQDA versionrn18.1and the results will be triangulated and displayed by tables, figures and texts. rnExpected outcome: High rate of depression, burden and disrupted quality of life andrndifferent significantly associated factors will be expected from this study. And the studyrnwill benefit the cancer patients, caregivers, and nurses at large. rnBudget: To conduct this project for about 40,419.30EB is needed.