Background- End-stage renal disease is known to have been on the rise becomingrnpublic health concern globally. The disease worsened due to the presence ofrncomorbidities conditions. The mortality rate and the reduced survival rate caused by therndisease are still the highest. Hemodialysis is a common treatment option for end-stagernkidney disease in Ethiopia. It improves the quality of life, reduces morbidity, andrnprolongs patient survival. Objective -This study was aimed to determine the survivalrnstatus and predictors of mortality among end-stage renal disease patients who undergonernmaintenance hemodialysis in Addis Ababa, Ethiopia, 2021. Methods- An institutionbasedrnretrospectivernrncohort study was conducted among end-stage renal disease patientsrnwho undergone maintenance hemodialysis between January 1rnstrn, 2014 and Decemberrn31rnstrn, 2019 using census sampling. The collected data were entered into epi data 4.2 andrnanalyzed using STATA 14. Kaplan-Meier survival curve and log-rank tests were used tornestimate the survival time and the presence of differences in survival among explanatoryrnvariables. Cox regression was used at a 5% level of significance to determine therninfluence of each explanatory variable on outcome variables. Result -A total of 157 endstagernrenalrndiseasesrnonrnhemodialysisrnpatientsrnwerernincludedrninrnthernfinalrnanalysis,rnofrnthosernrn37(23.6%)rnrnhad died. The overall mortality rate was 7.9 years per 100 person-year. Thernoverall estimated survival rate after the start of hemodialysis was 47.6% (95% CI: 30.6262.85%)rnrnat 72 months follow-up. Diabetes mellitus (AHR, 3.1, 95%CI: 1.13-9.73),rnbaseline albumin level