Background: Succinylcholine is a depolarizing skeletal muscle relaxant that remains thernaccepted standard for facilitating endotracheal intubation. This medication may cause somernadverse effects in patients such as hyperkalemia, malignant hyperthermia, increased intra gastricrnand intracranial pressure, fasciculation during induction, and postoperative myalgia. Althoughrnpostoperative myalgia are commonly encountered problem they may be very unpleasantrnexperiences for the patient till 24â€“48 h after surgeryrn.rnObjective: Comparison of defasciculation dose pancronium and mini-dose succinylcholine forrnpreventing succinylcholine induced muscle fasciculations and post operative myalgia amongrnsurgical patient in menelik II referral hospital.rnMethodology: An institutional based prospective cohort study conducted on 96 patientsrnundergoing elective surgery were divided in three equal groups :After pretreatment with eitherrn0.01mg/kg defasciculating dose of pancronium as Group (n= 32) , 0.2mg/kg mini dosernsuccinylcholine and 1ml NS group , patients were anesthetized with a 3-5mg/kg of Thiopentalrnfollowed by succinylcholine 2mg/kg. Data on baseline characteristics, incidence and severity ofrnmuscle Fasciculation and post operative myalgia (after 24 hours) were collected.rnResults: The demographic data of patients in three groups were comparable. The total incidencernof succinylcholine induced fasciculation were 17(53.1%) , 8(25%) and 30(93.8%) inrnpancronium, mini-dose of succinylcholine pretreatment and NS Groups respectivelyrn(p=0.000).The severity of fasciculation was reduced more in mini-dose succinylcholinerncompared with pancronium group (0.012) and Normal saline group (0.000).The total incidencernof myalgia was 6(18.8%) 3(9.4%)and 9(28.1%) in pancronium , mini-dose of succinylcholinernand Normal saline Groups respectively (p=0.158).There is no difference on the severity ofrnmyalgia between groups (p=0.161)rnConclusion and recommendation: pretreatment with mini dose of succinylcholine is effectivelyrnreduced the incidence and severity of succinylcholine induced fasciculation in comparison withrnpancronium and Normal saline group. but there was no difference in the incidence and severity rnof post operative myalgia between the three groups. We recommended to use mini dose of rnsuccinylcholine as a pretreatment to reduce succinylcholine induced fasciculation.