Background: Pain in children is often under recognized and undertreated. Conscious adults arernable to expresses their feelings or pain intensity whereas children are not aware or have arndifficulty on explanation of their pain. So, objective assessment and interventional managementrnis mandatory.rnObjectives: To assess knowledge, attitude and practice towards pediatric pain Managementrnamong nurses working in pediatrics unit at Tikur Anbessa specialized hospital, Addis Ababa,rnEthiopia.rnMethod: An Institutional based cross-sectional study was conducted among nurses working inrnPediatrics department of Tikur Anbessa Specialized Hospital from October to November 2020.rnA stratified random sampling technique was used to select 131 nurses. Data was collected usingrna standard self-administrated questionnaire, cleaned and entered using SPSS version 26. Datarnanalysis was done using frequency mean and percentages. Logistic regression model was used tornmeasure association between independent versus out-come variables considering the AOR, 95%rnCI and p < 0.05 as significant for all the independent variables.rnResult: Total number of 129 nurses with a response rate of 98.4% had participated in the study.rnMale to female ratio was 1:1.5.The result indicates that 61.2%, 58.1% and 52.7% of studyrnparticipants have adequate knowledge, favorable attitude and good practice towards pediatricrnpain management respectively. Pediatric work unit (pediatric OPD, NICU, and pediatric ward)were factors significantly associated with practice level towards pediatric pain management.rnConclusion & recommendation: Pediatrics unit nurses in TASH have adequate knowledge butrnunfavorable attitude and poor practice towards pediatrics pain management. Focused painrnmanagement training program and treatment protocol shall be developed to improve pediatricrnpain management.