Background: Inhalational exposure is common among the different health care providers,rnespecially in anesthesia care providers. Anesthesia providers have failed to identify personal rnprotective equipments.Knowledge related to occupational hazard prevention among thesernproviders was also low. rnObjective: To assess the Knowledge and practice of Anesthesia Providers on Exposure tornInhalational Anesthetic Agents in Tikur Anbessa Specialized Hospital. rnMethods: A hospital based cross-sectional quantitative study was conducted among 114rnavailable anesthesia providers in TASH, from 1 to 30 September 2020. Data was collected using rna structured self-administered questioner. Collected data was analyzed using spss version 26 andrnpresented with frequencies and percentages. For association between categorical variablesrnPearson chi square and logistic regression was used. rnResult: Out of 132 anesthesia care providers we were able to collect data in 114(86.36 % of therntotal population) participants. Although all feel exposed to inhalational anesthetics, Only rn64(56.1%) of the participants scored above the mean for knowledge on exposure to inhalationalrnanesthetics. Being female anesthesia care provider was strongly associated with good knowledgernscore on the risks of inhalational anesthetics. Only 63(55.3%) of the anesthesia care providersrnhave good practice in applying strategies to reduce exposure to inhalational anesthetic agents.rnThere was no strongly associated factor with practice of the anesthesia provider. rnConclusion: The knowledge on exposure to inhalational anesthetics agents and the practice inrnapplying the strategies to minimize exposure to inhalational agents in the Operating theatre is rngood. Being female anesthesia care provider was associated with better knowledge on the risksrnof exposure to inhalation anesthetics. Standard procedures of prevention of inhalationalrnanesthetics should be implemented by TASH.The standards can be given as a form of trainingrnfor anesthesia care providers and also put as a protocol by the department.