Background Anesthetists are prone to stress due to the nature of job and responsibility ofrnpatient situations in perioperative .High levels of stress are believed to affect anesthetists' healthrnand performance. . If the stress is not dealt with effectively, feelings of loneliness, nervousness,rnsleeplessness and worrying may result .Stress is the main problems that impends to deliveryrnquality anesthesia care in our set up, Stress is unavoidable but is not all bad. Too little stressrnleads to sleep, boredom and increase concentration, whereas too much stress gives us a sense ofrnpanic and tension. Acute and chronic stress is the most common form of stress in anesthetistsrntheir profession. It comes from demands and pressures of the recent past and anticipatedrndemands and pressures of the near future, such as their job of providing anesthetics or attendingrnpatient perioperative.rnObjectives of this study to assesses the prevalence of stress and associated factors uponrnanesthetists in AA.rnMethods is cross-sectional quantitative was chosen in the duration of February to May 2014.rnPSS(perceived stress scale structured questionnaires was developed and primary data collectedrnfrom AA anesthetists.rnResults Two hundred four anesthetists were participated in study . The response rate of thernstudy was 97.3%, their age ranged from 20 to 59 years . The majority were male: 115(56.4%).rnStudy participant of 51%( N=204) with 95%CI(0.44 to0.578%) become stressedrnConclusion, More than half of the anesthetists in Addis Ababa governmental as well as privaternhospital have defined work related stress. Statistically significant associated factors such as:-rnWatching football games TV/DSTV(movies), greater than 15days night duty per month,rnautomatic mechanical ventilation non function at all, excessive physical and mental workload,rncomplexity of the task, responsibility of the patient with ethical decision and fear of harmingrnpatient, mostly dissatisfaction on profession .