Albizia gummifera and Millettia ferruginia are plants found in Ethiopia that have differentrnmedicinal values. The objective of the present study was to evaluate the toxicological effects ofrnsub-chronic administered hydro-ethanolic (70%) seeds extract of Albizia gummifera and Millettiarnferruginea in albino Wistar rats. The seeds of these plants were collected from different areas ofrnEthiopia. They were dried and crushed to powder and macerated with hydro-alcohol and placedrnin orbital shaker. The extract was then filtered through Whatman filter paper No.1 and the filtraternornwas evaporated to dryness by Rota vapor and further concentrated by water bath at 40 C. Thernornextract was packed in air tight brown glass bottles and kept in a refrigerator at 4 C. The extractrnwas then administered to rats at different doses to determine the LD50 of the extract and at dosesrnof 125mg/kg/day and 250mg/kg/day for the sub-chronic toxicity study. The LD50 of Albizziarngummifera and Millettia ferrugina were found as 4000mg/kg and 3500mg/kg, respectively.rnStatistically significant difference in body weight was observed in female rats in the 10th week atrn250mg/kg body weight of seeds extract of Albizia gummifera administered group and in the malernrats at lowest dose during the 9th and 10th weeks of administration period for seeds extract ofrnMillettia ferruginea. The seeds extract of Albizia gummifera statistically decreased (p â‰¤ 0.05)rnMCH in the male rats at both doses; MCHC at both 125mg/kg and 250mg/kg in the female rats;rnand MCH in the female rats at higher dose and increased RDW-CV in the male rats at bothrndoses. It increased NEUT at the highest dose in both females and males. The seeds extract ofrnMillettia ferruginea decreased (p â‰¤ 0.05) in the MCHC and MONO of female rats at the highestrndoses. ALP, ALT and urea were found significant in the female rats administered with 250mg/kgrnof Millettia ferruginea seeds extract. While, seeds extract of Albizia gummifera increased onlyrnurea in male rats at 250mg/kg. Some histopathological changes in liver and kidney were alsornobserved for both plants extracts. There were inflammation, congestions and focal hepatocellularrnnecrosis of the liver tissue. The extracts also produced atrophy of the glomeruli of the kidney.rnThe observed changes in both of the plant seeds extract might have resulted because of thernpresence of some bioactive ingredients in the extract. Therefore, the active ingredients whichrnmight be responsible for toxic insult should be researched with their mechanisms of actions.rnKey words: Albizia gummifera, Millettia ferruginea, seeds, hydroethanolic extract, toxicity,rnWistar Albino Rats.