Histological And Functional Effect Of Fluoride On Cerebral Cortex Of The Brain

Fluoride is omnipresent in our environment and has been added to drinking water suppliesrnwith a recommended dose. Drinks, tooth pastes, mouth rinses, dietary supplements and foodsrnare also considered as sources of fluorides. This paper reviews the scientific literatures linkingrnfluoride with its effect on histology and function of cerebral cortex of the brain. In this paperrnthe role of fluoride in region specific and sub-cellular distribution of the brain with thernrelation of its neurotoxicity is highlighted. Studies were assessed by focusing on the dose ofrnfluoride, duration of exposure, type of experimental animals used to measure the effect ofrnfluoride. The literatures reviewed in the present paper used mice, rats and rat offspring asrnexperimental animals. From the literatures reviewed in the present paper, fluoride showed tornbe neurotoxic chemical which affects the biochemical content of brain, cause weight loss,rncause neurodegeneration, histological alternation in hippocampus and cerebral cortex of thernbrain, disrupting behavioral activities and cause reduction in cognitive and memory functions.rnKeywords: Cerebral cortex, Histopathological effect, Weight loss, Biochemical change,rnNeurobehavioral toxicity and Fluoride

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