As part of our attempts to synthesize Kosotoxin (1) simplernsynthetic procedures for the synthesis of related compounds !, ~,.rn52,· shown below have been developed. Furthermore D and F which arernkey intermediates for the synthesis of Kosotoxin analogues,. and!rnand Q which are supposed to be kosotoxin analogues have also beenrnsynthesized. In addition the chemistry of unsymmetrical condensa~rntion of acylated poly hydroxy compounds has been studied