Synthesis And Characterization Of Some Metal Complexes Of Schiff Bases Derived From Ninhydrin And A L-valine

Complexes of Mn (II), Fe (II), Co (II), Co (III), Ni (II) and Zn (II) with Schiff basernderived from ninhydrin and valine have been successfully synthesized. The complexesrnwere distinctly colored and were characterized by elemental analysis, molar conductance,rnInfrared and electronic spectral studies. The ligands were found to act as a mono basicrntridentate, ONO donor.rnSynthesis of metal complexes of the Schiff base derived from ninhydrin and cysteine wasrnunsuccessful.Variations between amino acids lie in the nature of side chain, whichrnconfers individuality upon each amino acids. Thus studies on the side chain,-SH , wererndone by taking in to consideration the properties of-SH group. With the assumption thatrnacidity of the group had an effect, acidic amino acid (tyrosine) was taken but the resultrnwas positive. It showed that acidity was not the reason for cysteine not forming metalrncomplex. The other property considered was the soft sulfur group, since the metals usedrnin the synthesis were hard, other soft metal (Cd(II)) was taken with the cysteine schiffrnbase itself and it has formed a metal complex. Hence, the reason for not forming metalrncomplex with first row transition metal is due to the soft side chain, -SH group.rnComparative anti microbial study of the complexes with the starting material ninhydrinrnwas undertaken against three bacteria. Enhanced activity than ninhydrin on the twornbacteria were observed

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