Sexually active adolescent females exposing to HIV/AIDS and STDs are high. A supportivernfather-daughter relationship is an additional buffer from these risks. Fathers who involved inrndaughters ' lives play an important role in influencing their sexuality. Thus, examining interactionrnfactors would enhance our understanding of adolescent females and their sexllality.rnA sample of 428 female students from seven colleges of Addis Ababa, who completed structuredrnquestionnaire, was incorporated in the study. Qualitative information was also obtained from twornfocus group discussions.rnOverall, about 34% of female students reported ever having had sexual intercourse. Of sexuallyrnactive female students, 57% reported having first had sexual intercourse without using condom.rnThe higher sexually active female students scored on a scale of perceived pa!.!rnal relationships,rnthe more likely they were to report ever having had sexual intercourse with condom, condom usernat last sexual intercourse and consistent condom use in the past six months (Odds ratios, 4.2, 5.1,rnand 6.3, respectively). Among sexually active female students, higher perceive father potential torndiscuss about sexuality and/or HIVIAIDS was positively related to condom use at last sexualrnintercourse and consistent condom use in the past six months (1.5, 1.3, respectively). Age ofrnfemale adolescents and father educational status were positively associated with Sexual risktakingrnbehaviors among sexually active female students.rnPaternal relationship may be a protective factor related to sexual risk-taking among sexuallyrnactive female students. Including activities that acknowledge the influence of paternalrnrelationships and facilitate positive father-daughter relationships may increase the efficacy ofrnprograms for reducing sexual risk-taking among college female students