Erta’Ale lava lake is located at the center of the Erta’Ale volcanic range in the northern afar depression. Erta’Ale is known by its two active lava lake situated at northern and central part of the caldera. The thesis generally considered the compositional variation of the Erta’Ale lava through time. Field investigation, petrographic and whole rock geochemical studies have been applied to meet the objectives. The lava of Erta’Ale volcano has MgO content ranging from (4.56-6.36 wt%) and SiO2 content (47-52 wt%) which decrease with increasing of MgO. The Al2O3 and CaO contents slightly increase with decreasing MgO down to ~6 wt%, and then decrease with decreasing of MgO a general positive trend for Fe2O3 and TiO2. The variations diagram of the Erta’Ale lava show fractionation of mineral phase. In most of the Erta’Ale lava (Ce/Pb > 20) crustal contamination is not major process. However there are some samples which have low value of Ce/Pb ratio (