The purpose of this descriptive study was to assess the motivation and job satisfaction of secondary school teachers in Bole sub city. A total of 69 respondents representing 25% of the 276 teacher population were selected randomly from six secondary schools. A lottery draw was made through a pre-numbered enrolled tickets coded separately for each school. In addition, 12 key informants (six principals and six vice principals for teachersâ€™ development) were included. Thus, there were a total of 81 study participants. Data was collected through a self-administered questionnaire filled by teachers and a semi-structured interview conducted by the researcher with the key informants. Data were analyzed through SPSS version 20 software. Descriptive statistics mainly mean values and standard deviations were compared during analysis. Results were presented in frequency tables, bar charts and pie diagrams. It was found out that more than half of teacher respondents, 55%, were motivated. However, the prevalence of job satisfaction was low reported only by 48% of teachers. Findings also show that job security, having additional responsibility other than teaching, pride in the profession of teaching, social relations and CPD were among the motivating factors. By contrast, the current supervision and evaluation practices were alleged to be improper as reported by teachers. Moreover, feeling of inferiority, low income and working conditions were identified by teachers as dissatisfying factors. It was concluded that motivation of teachers in the study area was moderate while job satisfaction was low. Recommendations are finally made pertaining to policy implementation, further study and mechanisms to enhance the job satisfaction of teachers.rnKey Terms: Motivation, Job Satisfaction, Teachers, CPD, Secondary School