Exercise is meant to minimize sedentary living, improve health and enhance physical fitness, performance and quality of life of individuals recovering from chronic conditions such as stroke. Most stroke survivors assume sedentary life style due to functional limitations which could be the reason behind their low quality of life. This study examined the effects of physical exercise on quality of life of stroke survivors in Osogbo, Osun-State. The objectives of the study were to investigate the effect of exercise on: (i) quality of life (QoL); (ii) well-being; (iii) functional capacity; (iv) cardio-respiratory endurance (VO2max); and (v) cardiovascular parameters (Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Heart Rate (HR) of stroke survivors in Osogbo, Osun-state.rnThis study employed pre-test, post-test experimental research design with a target population comprising all 25 registered male and female outpatients who were either right or left hemiplegic stroke survivors in the two tertiary hospitals at Osogbo, Osun-state. Purposive sampling technique was adopted to select all the 25 out-patients. However, during the intervention, four of the participants were excluded due to their inability to fulfill all the inclusion criteria. Finally, 21 participants formed the sample for this study. World Health Organization Quality of Life Questionnaire (WHOQoL) (2004) was adapted while reliability co-efficient of r = 0.90 was obtained using test retest method. A pilot study was carried out to ascertain the usability of the exercise programme and calibration of the instruments. The research questions were answered with descriptive statistics of frequency, percentage, mean and standard deviation while Analysis of Variance was used to test the hypotheses at 0.05 alpha level.rnThe Findings of the study were that:rn(i) aerobic, flexibility and strengthening exercise have positive effect on Quality of life of stroke survivors (47.0%) (p=0.00).rn(ii) aerobic, flexibility and strengthening exercise have significant effect on well-being of stroke survivors [F(2,19)=37.77, p=0.00].rn(iii) aerobic, flexibility and strengthening exercise significantly improved stoke survivorsâ€™ functional capacity [F(2,19)=69.37, p=0.00] .rn(iv) aerobic, flexibility and strengthening exercise significantly improved cardio respiratory endurance of stroke survivors [F(2,19)=5.29,p=0.008); andrn(v) there was a significant reduction in cardiovascular parameters (SBP [F(2,19) =4.209, p=0.031]; DBP [F(2,19)=6.65,p=0.018]); and HR[F(2,19)=5.29,p=0.015] of stroke survivors.rnThe study concluded that; physical exercise improves the quality of life, efficiency of cardiorespiratory fitness and functional capacity of stroke survivors. The implication of thisrnstudy is that improvements in quality of life of stroke survivors are possible with regular physical exercises. It was therefore recommended that; aerobic physical activity programme should be designed for outpatient stroke survivors with stable cardiovascular parameters after their discharge from the hospital using the exercise protocols.