Background: Disaster is a serious public health issue nowadays which can happen at any given instantrnand cause loss of many lives. Hence, the emergency room is at the forefront of the response system andrnserving as the gateway to the most appropriate care of victims. Health professionals who are working atrnthe emergency department have an upfront role in calamity responses to disaster victims. Adequaterncompetencies of health professionals to handle a disastrous event are important to care victims. rnObjective: The objective of the study is to assess the knowledge, attitude, and practice of healthrnprofessionals working at the emergency unit towards disaster, and emergency preparedness at AddisrnAbaba health bureau administered public hospitals, Addis Ababa,2020. rn Method: Cross-sectional study design was employed and three public hospitals randomly selected fromrnsix Addis Ababa health bureau administered public hospitals. A total of 225 health professionals who arernworking at the emergency unit of the selected hospitals participated in the study making the response raternof 96.2%, and data was collected using a self-administered questioner. Data were checked forrncompleteness, cleanness, and entered into EPI-data version 4.6.2.,and exported to SPSS version 23 forrnanalysis. Bivariate and multivariate analysis was employed. rn Results: The majority of the respondents 118(52.4%) were nurses and followed by physicians whichrnwere 63(18%). A significant proportion (34.7%) of the respondents did not know their hospitals had arndisaster plan. They have poor knowledge (52%), positive attitude (55.1%), and inadequate practicern(56.4%).Age category of the participant had influence level of knowledge and level of attitude at pvalue