Background-Blood and blood products are unique and precious national resources because theyrnare obtained only from individuals who donate blood. It contributes to saving millions of livesrneach year in both routine and emergency situations. At a minimum, the World HealthrnOrganization estimates that a country needs 1% to 3% of its population to donate blood to meetrnits need. Yet, many African countries including Ethiopia are far below the minimum bloodrncollection rate. rn Objective- To assess knowledge, attitude, practice, and associated factors towards voluntaryrnblood donation among non-health students of Addis Ababa University, Addis Ababa,rnEthiopia,2019.rn rnMethods-A cross-sectional study was conducted among 363 students in three selected non healthrncollegernstudents of Addis Ababa Universityrnwho were selected randomly.rnA stratifiedrnrandomrnsamplingrnprocedure was employedrnaccordingrnto the departmentsrnand yearrnof the study.rnArnrnpretestedrnself-administeredrnquestionnaire was used torncollect data.rnBoth bivariate andrnmultivariablernlogisticrnregressions were used to identifyrnassociated factors.rnrnResult- The proportion of students having good knowledge of blood donation, favorable attitudernand practice were 68%, 94.8% and 23.1 % respectively. Knowledge was significantly associatedrnwith Religion [(AOR=7.516, 95%CI: (1.313-43.018)] , information Heard/seen about bloodrndonation [AOR=6.184, 95%CI: (1.852-25.073)] and departmental grouping[AOR=3.326,rn95%CI: (1.457,7.589)].Attitude was significantly associated with Religion [AOR=6.72, 95%CI:rn(1.057-42.729)] and poor knowledge [AOR=.330, 95%CI: (.118-.919)].The practiced of rnvoluntary blood donation was significantly associated with Taking part in blood donation rncampaign[AOR=19.485, 95%CI: (9.082-41.802)] and poor knowledge [AOR=0.323, 95%CI:rn(0.144-0.726)]. rnConclusionrn: Significant numbers of students in this study have poor knowledge and practice ofrnblood donation while the level of attitude is good. Having taken part in blood donation rncampaigns and good knowledge about blood donation increased the odds of the practice of VBD