Background: Cancer is one of the major non-communicable diseases (NCDs), whichrninclude cardiovascular diseases, diabetes and chronic respiratory diseases. Cancer and its therapy rnmay lead to urgent conditions. The care of cancer patients with emergency problems presents arnchallenge not only to medical oncologists but also to clinicians involved in emergency medicine. rnThe main aim of this study is to analyze the clinical profile of oncologic patients presenting tornadult emergency department of Tikur Anbessa specialized Hospital. rn Methods: A prospective cross sectional study was conducted on oncologic patients whornpresented to emergency department of Tikur anbessa specialized hospital from February 2020 to rnJune. The area selected for this research was TASH adult emergency unit, Addis Ababa, Ethiopiarnwhere the sample was collected from the patients who fulfill the inclusion criteria. SPSSrnsoftware was used for analysis Univariate and bivariate analyses were performed for patientrndemographics and outcome. Multivariate logistic regression analysis was done to identifyrnindependent death-related factors. rn Result: Total of 306 patients were found during study period and included in this study, outrnof which 120(39.2%) of the patients were males and 186(60.8%) were females. The mean age rnwas 41.8Â±16.1. Most the patients (32.6) were initially seen in outpatient clinic of TASH.Aroundrn60% of patients visited ED 4 months after onset of illness. The most common malignancy wasrnhematology (n=107, 35%). Mean length of ED stay is3.16Â±1.86 days. Presentation by selfreferral,rnarrivalrnviarnambulancernandrnduringrnnight,rnlung,rnbreastrnandrnneckrnlocationrnofrncancer,rnhavingrnrnpoorrnrnECOG and having comorbidity (DM) were identified as factors associated with EDrnmortality of oncologic patients. rn Conclusion: Cancer patients frequently seek non-scheduled medical care and admit tornemergency departments for a range of conditions. Emergency physicians should develop rnconsensus algorithms in collaboration with the oncology to manage the commonly encounteredrnproblems.