Introduction: Postpartum hemorrhage is the most common leading cause of maternal mortalityrnworldwide a nd m ost of the de ath i s i n de veloping c ountries i ncluding E thiopia. G lobally, i t i srnresponsible for more than 25% of all maternal death and this proportion is higher in sub-SaharanrnAfrica. P ostpartum he morrhage c an b e m inimized a nd pr evented b y a pplication of a pr otocolrnknown as active management of third stage of labor. Proportion of deliveries assisted by a skilledrnbirth at tendant and antenatal c are co verage h ave b een u sed as a k ey proxy i ndicator f orrnmonitoring global p rogress to wards d ecreasing m aternal mo rtality. However, t hese t wornindicators may not reflect the content or quality of the care provider.rnObjective; The o bjective o f t his s tudy i s t o as sess K nowledge an d p ractice o f o bstetric ca rernproviders t oward active m anagement of t hird s tage of l abour (AMTSL) at h ealth c enters o frnFinfine area special zone of Oromia regional state, Ethiopia from April to May 2017rnMethods and materials; Institutional ba sed d escriptive c ross s ectional s tudy de sign w asrnimplemented. Whole health cen ters i n s elected t owns w ere i ncluded to th e s tudy w ith 118rnobstetric care providers from all health centers. Interviewer-administered structure questionnairernand observation by using observational check list was employed. Data was entered using EpidatarnV.3.1 and exported to SPSS version 21.0 f or statistical analyses. Descriptive statistical analysisrnwas u sed to p resent d ata w hile lo gistic r egression w ere us ed t o de termine a ssociation ofrnindependent variables with practice of obstetrics care providers.rnResults: Adequate know ledge on A MTSL was a chieved b y 40.7% of ob stetrics care providersrnwhile good practice on AMTSL was achieved by 18.6% of them. Sex, pre or in service training,rnaccess to reading materials and knowledge levels of obstetrics care providers were among factorsrnthat affects their practice on AMTSL.rnConclusions and recommendations: The overall know ledge and pr actice of obs tetric c arernproviders on A MTSL in the present study were not satisfactory. In views of the findings of thisrnstudy, it imp lies th at th e p ractice o f o bstetric c are p roviders w as mu ch lo wer th an th eirrnknowledge of AMTSL. The investigator calls for immediate interventions.rnKey Word; Knowledge, p ractice, A ctive m anagement o f t hird s tage of l abour, pos tpartumrnhemorrhage,Ethiopia