Background: Pressure ulcer is localized tissue necrosis that commonly develops on a bonyrnprominence areas when soft tissue compressed for prolonged period of time. Critically illrnpatients are considered to be at greatest risk for pressure ulcer development. So that, nurses arernthe first line health professionals to provide adequate care.rnObjectives: To assess knowledge and practice of Adult Intensive care Unit nurses and theirrnbarriers towards pressure ulcer prevention and management in selected public Hospital, AddisrnAbaba, Ethiopia 2017.rnMethods: A descriptive cross-sectional survey was carried out among (N=128) Adult Intensiverncare Unit nurses in six selected public Hospitals. Simple random Sampling techniques was usedrnto select sample hospitals in order to find research participants. In addition standardizedrnquestionnaire was used to collect data.rnResult: The study findings showed that the level of nursesâ€™ knowledge regarding pressure ulcerrnprevention and management was good (Mean=18.52, SD+2.686), while the level of nursesâ€™rnpractice was poor (Mean=12.39, SD+4.70924).Shortage of pressure relieving devices,rninadequate training and education and presence of other priorities other than pressure ulcers werernmajorly cited barriers to carry out PrU care efficiently. The nursesâ€™ knowledge has associationrn(AOR= 2.499, p value = 0.028) with training but not with their practice and barriers. In additionrnnursesâ€™ practice has significant association with barriers.rnConclusions: In general, the study results indicates that nurses have good knowledge of PrUrnprevention and management but accounts poor practice. As a result the study recommends forrnthe provision of in service training and fulfillment of proper equipments for AICU nurses andrnunit. The study finding implies the need for further researches and it will be used as point ofrnreference.rnKeywords: Pressure ulcer, Knowledge, Practice, Barriers