Background: Critically ill patients are usually treated in the intensive care unit (ICU) where the hospitalrnhighest mortality rates occur. Even though, few studies which had been conducted on specific singlerndiseases indicated that the magnitude and causes of ICU mortality in developed and rarely in developingrncountries, information on medical Intensive Care Unit (MICU) mortality pattern is essentially nonexistentrnin Ethiopia as in the rest of the world.rnObjective: The objective of this study is assessment of mortality pattern among patients admitted tornmedical ICU of TASH during the last five years (Sep2009-Aug2014), A.A, Ethiopia.rnMethodology: A retrospective chart review study was conducted from December 2014 to May 2015 inrnmedical intensive care unit (MICU) of TASH, A.A, Ethiopia. An appropriate structured checklist wasrnutilized for data collection.rnResults: Four hundred thirty six death charts were reviewed by using pretested structured check list.rnFrom these 223(51.1%) were males and 213(49.1%) were females. The overall mortality /magnitude ofrnmedical ICU death/ was 29%. Stroke is the leading cause of MICU death accounting for 15.8% followedrnby CHF (13.8%), AMI (8%), severe pneumonia (6.9%), HIV/AIDS (6.4%), sepsis (4.6%), shock (4.4%).rnMajority of deceased patients had deranged vital signs and changed mental states at MICU admission,rni.e. 97.5%, 95.4% , 86.2% , 84.9% , 70% , 53.4% had deranged pulse rate, respiratory rate, systolic bloodrnpressure, diastolic blood pressure, oxygen saturation and body temperature respectively and 44.3% andrn43.3% were comates and confused mental states respectively. The leading complication/immediaterncause of death/ was respiratory failure accounting (32.8%) followed by shock (23.9%), multi organrnfailure (22%), cardiovascular failure (16.1%), cardiopulmonary arrest (3%) and central nervous systemrnfailure (0.9%).rnConclusion and Recommendation:rnThe overall medical ICU mortality remains high, non-communicable diseases are posing significantrnhealth problems in terms of mortality and among all non-communicable diseases, stroke and cardiacrndiseases were the most important health problems in terms of MICU mortality. Set up and strengthenrnnational non-communicable diseases control program. Programs promoting public awareness and lifernstyle changes to prevent non-communicable diseases need to be promoted. Further studies should bernconductedrnonrnadmissionrnandrnoutcomesrn~ ix ~rnofrnpatientsrninrnmedical