Distilleries are among the existing industry which produces high effluent volume characterized with highrntemperature, low PH, very high COD and BOD, which is potentially dangerous to the environment if itrnis discharged without effective treatment. Therefore, this study is conducted to determine kinetic datarnwhich is crucial for effective treatment of this high volume distillery effluent using activated sludgernprocess.rnIn this thesis work samples for the laboratory experiment were taken from Metehara sugar factory, withrnthe following characteristic pH 3.8 â€“ 4.5, COD 92,000 mg/L, BOD 45,410 mg/L, TS 49,950 mg/L,rntemperature 89 â€“ 98 oC , Nitrogen 1150 mg/L and phosphorous 4100mg/L. In the determination of thernkinetic coefficients, Michaelis-Menten relation for continuous process was used. Chemicals which arernused in this experiment are ATH to avoid nitrification, KOH to absorb CO2and Na (OH) to maintain pH.rnDuring the study, performance of a laboratory-scale biological treatment unit for the distillery waste wasrnevaluated and the kinetic parameters for the activated sludge process were determined. A laboratory-scalerntreatment unit comprising aerobic digester and final clarifier was used for this purpose. The treatment unit wasrnoperated continuously for 270 days by varying the hydraulic retention times from 2 to 9 days. The biologicalrnoxygen demand (BOD) of the influent and effluent and the mixed liquor volatile suspended solids of thernaeration tank were determined at various detention times to generate data for the kinetic coefficients.rnThe kinetic coefficients k (maximum substrate utilization rate), Ks(half velocity constant), Y (cell yieldrncoefficient), and Kd (decay coefficient) were found to be 4.46 per day, 534 mg/L, 0.714, and 0.038 per day,rnrespectively, based on BOD and MLVSS in the reactor. These coefficients used for the design of reactorrnvolume and sludge handling facility for activated sludge process