The increase in comprehensive socio-economic activities have resulted in considerable changesrnin the land use and land covers of Melka hombole watershed of the Upper Awash sub-basin ofrnEthiopia for the last years. This study examines, thus, the changes in hydrological processes inrnresponse to changes in land use and land covers during the period 1995-2015 by integratingrnremote sensing, GIS and Hydrological modeling. Land use land cover classifications for 1995,rn2005, and 2015 were conducted by employing supervised approach of classification image. Thernaccuracy assessment result revealed that the overall accuracy of 87.71% was achieved for therncurrent image classification. Kappa coefficient was found 0.97. Post classification comparisonrntechnique was applied to detect the changes in land use land cover. The LULC change analysisrnrevealed that the cultivated land, urban and water body have increased by 14.23%, 3.05% andrn0.12% respectively and that of grass land, woody vegetation, wetland and bare lands decreasedrnby 9.15%, 8.34%, 0.06% and 0.04% respectively during the study period of 1995-2015. Thernthree generated land cover maps were, then, used to run the Arc SWAT model so as to evaluaternthe impacts of the detected land use and land cover changes on the stream flow. Sensitivityrnanalysis, calibration, and validation of the model simulation were conducted and 12 parametersrnwere identified to be sensitive for the stream flow and were used for further model calibrationrnand validation. Calibration was executed using the observed stream flow data of Hombolerngauging station from 1998 to 2007 leaving 3 years of warm up period. Consequently, validationrnwas undertaken from 2008 to 2015. Both the calibration and validation results revealed a goodrnmatch between measured and simulated stream flow expressed by a coefficient of determinationrn(R2rn) of 0.82 and that of Nash-Sutcliffe Efficiency (ENS) value of 0.81 for the calibration, and arnvalue of 0.76 and 0.75 for the validation period respectively. Then the model was run to obtainrnthe values of surface runoff and ground water return flows for the three respective time periods.rnThe result indicated that the mean monthly stream flow for wet season has increased by 19.63%rnand has decreased 30.74% for dry months. Total water yield of the watershed has increased byrn21.67%. Generally, surface runoff has increased by 38.69% while lateral flow decreased byrn21.82% during the study period owing to the increase of cultivated and urban lands and decreasernof vegetation cover. The annual actual evapo-transpiration has decreased by 16.34% from 1995rnto 2015. Therefore, the results confirmed that the hydrological processes of the study area havernchanged due to land use and cover changes undertaken in the past two decades.