Water quality refers the characteristic of water that influence its suitability for particular use that rnis how well the quality meets the needs of specific use. Good quality water has social, rneconomical and environmental benefits and determined by its physical, chemical and biological rncharacteristics. In our country the quality of water deteriorated through time due to various rnnatural and anthropogenic activities. Awash River is one of the rivers found in our country and rnserves as a drinking source for millions of people. But it has been impaired by various types of rncontamination due to waste released from different socio - economic activities in its basin. This rnmakes the lower awash community to depend on poor and unsafe water consumption that rnexposes them to water quality related health risks. The aim of this study was to investigate the rnimpacts of wastewaters from Metehara sugar factory on the water quality of Awash River. Both rnthe effluents and the river water samples at selected points were analyzed for physicochemical rnparameters. The results for different parameters range for turbidity (21.85-192 NTU), EC (518-rn17,590 518ÂµS/cm), temperature (20.5-44.5 0rnc), phosphate (0.785-2.85 mg/L), COD (745-89,290 rnmg/L), BOD5 (476 mg/L-71,457 mg/L) and oil and grease (30-77 mg/L) were the major drinking rnwater quality concern in Awash River which were higher than Ethiopian (CES 58) and WHO rnmaximum allowable limit of drinking water standard. Most of the river samples result also rnshown variation after dissolved with wastewaters. This clearly indicates the pollution load of rnwastewaters. The river is threatened by factory's wastewaters and might induce health risk. rnTherefore, there should be up to date treatment plant for factory wastewater and continuous rnmonitoring and evaluation of the effluent quality before discharging into the river should be rncarried out