Lead (Pb) poisoning in the environment and humans an increasing global public health concern. Lead is a hazardous metal that has negative health and environmental consequences. While lead poisoning is dangerous to adults, also toxic to occupational employees and children, and the health impacts are often irreversible and can have a lifelong impact (WHO, 2015). The purpose of the study is to investigate the Effect of lead based paints industry on environment and human health in Addis Ababa, Ethiopia. A simple structure questionnaire and KII (Key Informant Interviews and laboratory analysis of 12 samples collected from five paint factories by using atomic Absorption Spectrophotometry (AAS) that used to determine the concentration of lead in paint industry and also Logistic regression is useful for situations in which able to predict the presence or absence of a characteristic or outcome based on values of a set of predictor variables to evaluate the perception of the community/paint factory employeeâ€™s was undertaken. Results of this study indicated that, based on the laboratory analysis from different five paint factories, out of a total of 12 samples, Zhi bin Wang, Global Paint and Rainbow paint factoryâ€™s analyzing 7 paints sample which is (58.3 %) the lead content was greater than 90 ppm while Nefas Silk and Kadisco paint factory analyzing 5 paint sample (41.7%) below 90 ppm or very far from standard level.. These results indicate that lead paint is commonly being sold for residential and other consumer applications in Addis Ababa without any consumer warnings. Awareness of the community/paint factoryâ€™s employeeâ€™s on the impact of lead on health and environment found to be minimum.rnTherefore, decision makers/ regulatory institution has to be monitored and evaluate effective implementation and corrective measures on paint firm owners in order to avert environmental pollution through awareness creation for community in Addis Ababa to ensure environment and health safeguard.