Earthquake with its damaging occurrence along fault line causes failure of buildings. This could be reduced by introducing materials that can withstand seismicity as against large sections used in conventional frame building (CFB). Conventional method of anti-seismic technique increases the stiffness of structures by enlarging structural elements, which accommodates seismic load because of the added mass to structures, this increase the weight of building while the safety level is little improved. The aim of this study was to investigate Cold-formed steel Concrete (CSC) frame building with Strawbale infill panels (SIP) under seismic loadings. The objectives were to: (i) assess a 4 storey CSC frame symmetric building with strawbale infill panel; (ii) perform numerical modeling and analysis of theCSC frame building with SIP; (iii) determine the building response to seismic loadings; and (iv) compare the behaviour of CSC frame building model with SIP to the behaviour of CFB model with sandcrete block masonry infill panels.rnThe 4 storey CSC frame building model with SIP was assessed by identifying capabilities of its material properties to resist seismic loading activities.The building geometry, location of soil conditions, location of building with respect to seismicity and ductility parameters and applied loads were considered in the modeling of the building.Numerical modeling of CSC frame building with SIP was done and subjected to seismic load using Response Spectrum Analysis (RSA) and 5 Time History (TH) data. Data obtained from Haiti earthquake of 2010 was used for the RSA in accordance withEurocode8, while the 5 TH data were obtained from Elcentro, Petrolia, Northridge, Lucerne and Slymarff earthquakes.ETABS 2016 software was employed for the modeling and analysis of the building and the results of both analyses were subjected to safety verification in accordance with Eurocode 8.A similar CFB was then modelled and compared to theCSC building with SIP.rnThe findings of the study were that:rn(i) the CSC frame building with SIP offered 25.3% more of resistance to external forces;rn(ii) building model showed a total weight of 16067.11KN and modal analysis of first 6 modes ranged between 0.644 to 0.117 periods;rnxivrn(iii) response of building model under RSA revealed that maximum displacement of 127.85mm occurred at the top of the building while the maximum drift of 0.016 occurred on the first storey.rn(iv) five THanalysis showed that the maximum displacement occurred at the top level for all five earthquake data used, with Petrolia earthquake data having the highest displacement value of 50.35 mm, and a maximum storey drift value of 0.0068; andrn(v) CSC frame building with SIP under seismic load has a storey drift of 0.0068 compared to CFB with drift value of 0.00912.rnThe study concluded that the maximum displacement and drift of CSC frame building with strawbale infill panel under seismic load occurred at the top of the building. The study recommended that CSC building with SIP be incorporated in building standard, as this composition is more stable under earthquake than CFB.