Locally manufactured pharmaceutical products are a type of product that contains the same active pharmaceutical ingredients as the brand product, with similar pharmacodynamics and pharmacokinetic properties. This indicates that generic products have the same as the brand product in dosage, safety, effectiveness, strength, stability, and ways of administration to patients. Therefore, the current study aimed to determine factors affecting the attitude of community pharmacists towards locally manufactured pharmaceutical products in Addis Ababa, Ethiopia. There are several research designs in use based on the nature and type of the research being done. In this study, a cross-sectional study design with a quantitative approach was used. A semi-structured questionnaire was utilized to collect data from community pharmacists working in community pharmacies in Addis Ababa, Ethiopia. In the regression analysis of variables, three variables were associated with community pharmacists attitude towards locally manufactured pharmaceutical products. These are; maximum educational status, professional status, and year of experience in community pharmacy practice. Those community pharmacists having masters in pharmacy and other fields had a better attitude towards locally manufactured pharmaceutical products with AOR = 2.49, CI (1.213 – 4.343) and AOR = 2.13, CI (1.203 – 4.123), respectively when computed relative to a bachelor pharmacy degree. When compared to owners of the community pharmacy, community pharmacists and managers at community pharmacies had 2.1 [AOR = 2.10 (1.439 – 6.435)] and 1.9 [AOR = 1.50 (1.010 – 2.830)] times higher attitude, respectively. In conclusion, the attitude of community pharmacists was inadequate that requires an intervention to optimize locally manufactured pharmaceutical products utilization. Educational qualification, employment position, and work experience were shown to be the determinants of participants’ attitudes. Lack of belief in locally manufactured pharmaceutical products, substitution agreement with the prescriber, cost-effectiveness of locally manufactured pharmaceutical products, and consumer preference/demand were the most influencing reasons for the selection of locally manufactured pharmaceutical products.rnKey Words: Locally Manufactured Pharmaceutical Products, Attitude, Community Pharmacist, Ethiopia