Teff is one of the major cereal that is used for making the Ethiopian staple food injera. Although studies have shown that teff has a good nutritional composition, whether this can be affected by various fertilizer applications remains unknown. The purpose of this study was to investigate the effect of organic and inorganic fertilizer treatments on nutrient composition, phytochemical composition, mineral content and anti-oxidant capacity of teff using DPPH (Diphenyl Picryl Picryl Hydrazyl) free radical scavenging activity. The kora teff variety was sown in an experimental field and was subjected to inorganic (recommended NP) and organic (recommended vermicompost and recommended compost) fertilizers. Standard methods were used to analyze the proximate composition, mineral content (Fe, Ca and Zn), phytochemicals (phytic acid and total phenolic content) and anti-oxidant capacity of teff with fertilizer treatments using DPPH. Teff grains with 50% recommended NP+50% recommended vermicompost had high protein content, calcium and phytic acid than others. Teff grain with recommended compost had the highest in iron content and scavenged the most free radical scavenging capacity at a lowest IC50 value accompanied by highest phenolic contents. Teff grains with recommended vermicompost were the highest in thousand kernel weight and bulk density than the others (p