Flooding causes major damage on the economic, social and environment of the affectedrnarea. Overflow of Meki River has affected and displaced the people and destroyed farmrnland along the river in the flood plain area of Dugda Woreda in the summer season. In laternMarch and early April 2016 floods destroyed 485.75 hectares farm land and damage 80rnfarmer houses. This research develops flood hazard maps and damage analysis along MekirnRiver. The digital elevation model of the study area was used to extract the physicalrncharacteristics of the catchment using HEC-GeoHMS GIS extension. HEC-HMSrnhydrological model was used to generate flow hydrograph for different return periods at thernoutlet of the catchment using the design rainfall. Flood inundation and hazard maps alongrnMeki River have been developed based on the flow hydrographs for different return periodsrnusing the HEC-RAS model, GIS for spatial data processing and HEC-GeoRAS forrninterfacing between HEC-RAS and GIS. Based on the output of HEC-RAS hydraulic model,rnusing HEC-FDA, flood damages were estimated quantitatively. The areas along the MekirnRiver simulated to be inundated for 2, 5, 10, 20, 25, 50 and 100 years return period. Thernflooded areas were high from Meki town to Lake Ziway for all return periods. The floodrninundated area along the Meki River for a return period of 100, 50, 25, 20, 10, 5, and 2rnyears were 15.52, 14.99, 14.02, 13.57, 12.95, 12.50 and 11.52 kmrn respectively. The floodrnhazard map results were low, moderate, high and very high hazard levels based on the floodrndepths generated using HEC-GeoRAS GIS extension. Finally, the cost of flood damages wasrnevaluated using HEC-FDA and mitigation measures were proposed to reduce the damagesrndue to flooding in study area. The sum of expected annual damage for eight return periodrnintervals was 707,193,871 birr. The major findings in the study indicate that inundatedrnareas in the lower part of Meki River were made economic damage on agricultural farmrnland and settlement. Therefore, increasing the width of the river channel or construction ofrnlevees has been proposed to reduce the economic damage of flooding in lower river parts.